I can confirm this install method (source) worked with a Raspberry Pi 4 using Raspbian Buster.
Compiles Vice and installs into /usr/local/bin. Initial launch reports a sound issue. If you go into settings (F12), there’s a sound configuration you can change to “Alsa”.
# get dependencies – this may take a long time and ~ 1.5 GB
sudo apt install autoconf automake build-essential byacc dos2unix flex libavcodec-dev libavformat-dev libgtk2.0-cil-dev libgtkglext1-dev libmp3lame-dev libmpg123-dev libpcap-dev libpulse-dev libreadline-dev libswscale-dev libvte-dev libxaw7-dev subversion texi2html texinfo yasm libgtk3.0-cil-dev xa65 libsdl2-dev
The 8bitdo Genesis Receiver allows your Sega Genesis or Mega Drive to use a modern gamepad such as the PS4, PS3, XBox or Wii U (pictured) as well as a wide assortment of Bluetooth controllers. Also pictured on the right is another device used in a similar way for devices that accept USB such as the Nintendo Switch, the Mini Playstation, PCs, etc.